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Inhibition of in Vitro Paroxysmal Nocturnal Hemoglobinuria Lysis by Tryptophan Metabolites.

Kenneth S. Graff; Charles E. Mengel, M.D., F.A.C.P.; and Stanley P. Balcerzak, M.D.
Ann Intern Med. 1968;68(5):1168. doi:10.7326/0003-4819-68-5-1168_1
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In vitro lysis of paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes presumably results from the unique interaction between these cells and the third component (C′3) of complement without the requirement for antibody and early phase reactants (C′1, C′4, C′2). Since various aromatic amino acid derivatives had been shown to inhibit C′3 in other systems, we examined the effects of some tryptophan metabolites on the HAM acid-serum lysis and the sucrose lysis tests of natural PNH and glutathione (GSH)-treated erythrocytes. Our previous studies had shown GSH-treated red cells to be indistinguishable from those of PNH patients. A range of 0 to 99% inhibition


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