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Abstracts |

Evaluation of Iron Stores by Chelates.

L. A. Harker, M.D.; D. D. Funk, M.D.; and C. A. Finch, M.D.
Ann Intern Med. 1968;68(5):1168. doi:10.7326/0003-4819-68-5-1168_2
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Storage iron is widely dispersed within the reticuloendothelial and parenchymal cells of the body. The iron within reticuloendothelial cells represents normal stores, and reticuloendothelial iron overload is clinically benign. In contrast, increased parenchymal iron deposits are associated with the manifestations of hemochromatosis. The possibility of differentiating these two types of storage iron by the synthetic chelates was investigated. In 120 human subjects measurements were made of plasma iron, total iron-binding capacity, liver and marrow biopsies, plasma iron turnover, and urinary and fecal iron excretion after deferoxamine and DTPA. In addition, the distribution of 59Fe-tagged feroxamine was determined in urine, stool,


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