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Polycythemia (Erythrocytosis) Associated with Uterine Fibroids: A Case Report with Erythropoietic Activity Demonstrated in the Tumor.

Edward J. Hertko, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1169. doi:10.7326/0003-4819-68-5-1169_1
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Since 1953 the association of polycythemia with uterine fibroids has been reported 13 times. Various theories have been advanced as to the possible cause of the polycythemia, but none have been proved. One of the theories advanced was that the tumor might produce erythropoietin (erythrocytosis stimulating factor—ESF). This factor has been shown to be the etiological agent in the development of polycythemia associated with other tumors, such as renal carcinoma, cerebellar hemangioblastoma, and renal cysts.

I have had a recent patient with polycythemia associated with uterine fibroids. After surgical removal of the fibroids her blood count returned to normal levels


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