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The Nature of the Vascular Lesion in Thrombotic Thrombocytopenic Purpura.

Hau C. Kwaan, F.R.C.P.(Edin.); Guillermo Gallo, M.D.; Elizabeth Potter, M.D.; Hunter Cutting, M.D., F.A.C.P.; and Robert Stanzler, M.D.
Ann Intern Med. 1968;68(5):1169-1170. doi:10.7326/0003-4819-68-5-1169_3
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Despite evidence of extensive intravascular microthrombi formation in thrombotic thrombocytopenic purpura (TTP), there is absence of defibrination suggesting an unusual type of vascular lesion. Three patients with TTP were studied in an attempt to clarify the nature of these lesions. Tissues were studied by the histochemical fibrin slide method for plasminogen activator and by the immunofluorescent method for fibrinogen, gamma globulin, and B-1-C complement. The plasma was assayed for plasminogen activator, inhibitors of fibrinolysis, fibrinogen, plasminogen, and factors V, VII, VIII, and IX. Characteristic vascular lesions with thrombi formation were seen in all the tissues studied. Immunofluorescent studies revealed bright


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