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The Qualitative Platelet Defect in Chronic Renal Insufficiency.

C. L. Lutcher, M.D.; G. A. Porter, M.D.; and A. J. Seaman, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1170. doi:10.7326/0003-4819-68-5-1170_2
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A qualitative platelet abnormality exists in certain patients with renal failure. We studied this phenomenon in five patients with bleeding due to severe chronic renal insufficiency. The defect was characterized by a prolonged Ivy bleeding time and decreased prothrombin consumption in all five patients. Other routine coagulation studies were normal. Intravascular observations using blood from these patients to perfuse the living extracorporeal eye (Arch. Intern. Med. (Chicago) 119: 600, 1967) were made. Most significant was the failure to form platelet aggregates upon the addition of adenosine diphosphate to their blood.

Ivy bleeding times and prothrombin consumption tests remained abnormal in


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