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Studies on the Evolution of the Hypercoagulable State in Patients with Thrombotic Diseases.

Arthur J. Samuels, M.D., F.A.C.P.; and Florence Lepowsky
Ann Intern Med. 1968;68(5):1172. doi:10.7326/0003-4819-68-5-1172_1
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Six patients with unequivocal evidence of a hypercoagulable state were studied through one, two, or three complete cycles of exacerbation and remission. Included were patients with [1] purpura fulminans, [2] acute leukemia with migratory thrombophlebitis, [3] anaphylactic reaction after intravenous injection of iron, [4] prostatic carcinoma, [5] migratory thrombophlebitis after ingestion of an oral gestagen, [6] migratory thrombophlebitis, inferior vena cava thrombosis, and pulmonary emboli occurring on two separate occasions, in each instance after 2 weeks of oral gestagen therapy.

Studies included hemoglobin, volume of packed red blood cells, leukocyte count, absolute differential leukocyte count, platelets, clotting time in plastic


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