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Abstracts |

Splenic Transplantation for Hemophilia.

Herbert S. Sise, M.D., F.A.C.P.; Victor H. Covelli, M.D.; and John C. Norman, M.D.
Ann Intern Med. 1968;68(5):1172. doi:10.7326/0003-4819-68-5-1172_2
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Perfusion of human and porcine spleens ex vivo with various types of priming volumes has confirmed that the spleen is a major potential source of antihemophilic factor (AHF). The response of the spleen is dependent on a trophic factor in the plasma of patients with hemophilia. Thus, normal autologous, homologous, or heterologous blood primes did not evoke a rise in the level of AHF in the perfusing volume. Bloods from hemophilic patients and two bloods from subjects whose AHF levels were falling caused a progressive increase in the level of AHF in the perfusate over the course of the 4-hr


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