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Cerebrospinal Fluid Lactic Dehydrogenase Isoenzymes in Bacterial Meningitis and Viral Meningoencephalitis.

Harry Beaty, M.D.; and Stephen Oppenheimer, M.D.
Ann Intern Med. 1968;68(5):1174. doi:10.7326/0003-4819-68-5-1174_1
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Granulocytes are rich in lactic dehydrogenase (LDH) isoenzymes 4 and 5, whereas 1 and 2 predominate in brain tissue. Measurement of total LDH and isoenzyme patterns was undertaken to provide an assessment of the degree of inflammation and its significance in bacterial and viral meningitis. Specimens of cerebrospinal fluid (CSF) were obtained from 11 patients with bacterial meningitis and 9 patients with viral meningoencephalitis, and total and isoenzyme concentrations of LDH were determined. The peak level of LDH in the CSF of patients with Haemophilus influenzae and Diplococcus pneumoniae meningitis ranged from 119 to 243 units, whereas in patients infected


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