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Abstracts |

Cephaloridine and Cephalothin: Pharmacodynamics in Uremia.

R. L. Perkins, M.D., F.A.C.P.; E. Smith, M.D.; and S. Saslaw, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1175. doi:10.7326/0003-4819-68-5-1175_3
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The high antibacterial activity of cephalosporins suggests their use in uremic patients. Preliminary reports indicate that high and prolonged, potentially toxic serum levels of cephalosporins may occur in uremia and that peritoneal dialysis may significantly reduce concentrations. Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically uremic patients before and during peritoneal dialysis. After single 1-g intramuscular injections, decay rates were determined for antibiotic concentrations and antibacterial activity (ABA) in serial serum, urine, and dialysate samples. Cupplate antibiotic assays were obtained using Sarcina lutea; ABA was determined against a penicillin-resistant staphylococcus, group


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