0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Abstracts |

Cephaloridine and Cephalothin: Pharmacodynamics in Uremia.

R. L. Perkins, M.D., F.A.C.P.; E. Smith, M.D.; and S. Saslaw, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1175. doi:10.7326/0003-4819-68-5-1175_3
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The high antibacterial activity of cephalosporins suggests their use in uremic patients. Preliminary reports indicate that high and prolonged, potentially toxic serum levels of cephalosporins may occur in uremia and that peritoneal dialysis may significantly reduce concentrations. Thus, the comparative pharmacodynamics of cephalothin and cephaloridine were evaluated in a crossover study in five chronically uremic patients before and during peritoneal dialysis. After single 1-g intramuscular injections, decay rates were determined for antibiotic concentrations and antibacterial activity (ABA) in serial serum, urine, and dialysate samples. Cupplate antibiotic assays were obtained using Sarcina lutea; ABA was determined against a penicillin-resistant staphylococcus, group

...

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)