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The Serologic Diagnosis of Disseminated Candidiasis in Patients with Acute Leukemia.

Harvey D. Preisler, M.D.; Herbert F. Hasenclever, Ph.D.; and Alexander A. Levitan, M.D.
Ann Intern Med. 1968;68(5):1176. doi:10.7326/0003-4819-68-5-1176_1
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Disseminated candidiasis is an increasingly important cause of morbidity and mortality in patients with leukemia. The incidence has been reported as 29%, 19%, and 12% (Bodey, 1966; Gruhn, 1963; Schumaker, 1964). The diagnosis, however, because of lack of adequate techniques for detection, is usually made on postmortem examination. In an attempt to facilitate the antemortem diagnosis of this disease the authors undertook a retrospective study to determine the presence of circulating agglutinating antibodies to heat-killed Candida albicans. Serial serum samples that were collected during the terminal 1 to 5 months of life of 33 patients who died with acute leukemia


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