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Abstracts |

The Place of Steroids in the Nephrotic Syndrome.

D. A. K. Black, M.D., F.R.C.P.
Ann Intern Med. 1968;68(5):1178-1179. doi:10.7326/0003-4819-68-5-1178_3
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A multicenter controlled trial was begun in 1962, under the auspices of the Medical Research Council, to evaluate steroids in the nephrotic syndrome in adult patients. Only patients whose biopsies showed glomerulonephritis were included, under the histological categories "minimal glomerular change," "proliferative," and "membranous." Patients were randomly allocated to "prednisone" and "control" groups. Both groups received diuretic and other general treatment, but the "prednisone" group received in addition prednisone in the range of from 20 to 40 mg/day for at least 6 months.

In patients with minimal glomerular change, there was a significant and prompt reduction in proteinuria in the


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