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Clinical Aspects of Membranous Nephropathy.

Jacob Churg, M.D.; Theodore Ehrenreich, M.D.; Marvin H. Goldstein, M.D.; Edith Grishman, M.D.; Kurt Lange, M.D., F.A.C.P.; Jerome G. Porush, M.D., F.A.C.P.; and Stuart L. Yunis, M.D.
Ann Intern Med. 1968;68(5):1179. doi:10.7326/0003-4819-68-5-1179_1
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Membranous nephropathy is a primary renal disease characterized by diffuse thickening of glomerular capillaries and massive proteinuria with nephrotic syndrome. It is also known as membranous glomerulonephritis and Ellis type II nephritis. Capillary thickening is caused by proteinaceous subepithelial deposits and progressive widening of the basement membrane. Among 60 patients there was a slight male preponderance. The ages ranged from 3 to 79 years, almost half being in the 40 to 60 age group. The duration of disease ranged up to 17½ years, and the average follow-up was 3 years. In three fourths of the patients there was a full-blown


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