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Serial Studies of Glomerular Filtration Rate and Renal Plasma Flow in Transplant Donors, Identical Twins, and Allografts.

William J. Flanigan, M.D.; Robert O. Burns, M.D.; Frank J. Takacs, M.D., F.A.C.P.; and John P. Merrill, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1180. doi:10.7326/0003-4819-68-5-1180_1
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Serial studies of inulin and para-aminohippurate clearances were done on kidney transplant donors to determine the magnitude of the adaptive increase in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) that occur after unilateral nephrectomy. The results obtained in 24 donors have been compared with results of similar studies in 19 recipients, of which 7 were isografts (identical twins) and 12 were allografts. The results have been expressed as a percentage of the donor's prenephrectomy clearances. Average GFR and ERPF in the donor group during the first week after surgery were 67% and 65%, respectively, of the original


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