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Effects of Prolonged Administration of Oxygen on the Pulmonary Hypertension of Patients with Chronic Bronchitis and Emphysema.

J. M. Bishop, M.D., F.R.C.P.; A. S. Abraham, M.R.C.P.; and R. B. Cole, M.R.C.P.
Ann Intern Med. 1968;68(5):1184. doi:10.7326/0003-4819-68-5-1184_1
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Evidence of the role of hypoxia in the causation of pulmonary hypertension in patients with chronic bronchitis and emphysema has hitherto received little support from studies in which oxygen was administered, with little or no fall in pulmonary arterial pressure. We have found that when 28% oxygen is given to such patients during an acute illness with respiratory failure the effect is considerably greater.

In further studies 28% oxygen was given to six patients in a stable state continuously for periods of 4 to 8 weeks. Serial observations were made during this time, using the "floating catheter" technique to measure


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