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Abstracts |

The Pathogenesis of Diffuse Pulmonary Fibrosis: An Ultrastructural Study.

D. H. Bowden, M.D.; and J. P. Wyatt, M.D.
Ann Intern Med. 1968;68(5):1184-1185. doi:10.7326/0003-4819-68-5-1184_3
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Study of the pathology of the end stages of diffuse idiopathic pulmonary fibrosis rarely provides any indication to the pathogenesis of the process.

This investigation was directed to the elucidation of the end phases by the ultrastructural study of lung biopsies. In the early stages of pulmonary fibrosis two distinctive tissue responses may be observed. One, which is characterized by a florid alveolar cell proliferation and desquamation, suggests that the injury is primarily of an epithelial nature. The other, exemplified by such clinicopathologic conditions as "alveolar proteinosis" and "diffuse pulmonary hemosiderosis," indicates that the dominant site of injury is in


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