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Abstracts |

Thrombolytic Therapy with Urokinase in Pulmonary Thromboembolism.

Edward Genton, M.D. (Associate); and Phillip S. Wolf, M.D. (Associate)
Ann Intern Med. 1968;68(5):1186. doi:10.7326/0003-4819-68-5-1186_1
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Thrombolytic therapy with the plasminogen activator, urokinase (UK), was evaluated in 13 patients with angiographically confirmed bilateral massive pumonary thromboembolism. UK was administered intravenously for 8 to 12 hr at a rate of 1,500 to 2,000 CTA units/lb per hour. In group 1 (five patients) all symptoms occurred within 2 weeks before UK with fresh emboli within 72 hr. Average mean pulmonary artery pressure equaled 38 mm Hg. Each had marked symptomatic blood gas and angiographic improvement after UK, and mean pulmonary artery pressure fell to 24 mm Hg. Group 2 (four patients) had symptoms longer than 2 weeks, plus


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