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Abstracts |

Positive Antinuclear Factor in Patients with Chronic Lung Disease.

Hiroshi Nagaya, M.D.; C. Edward Buckley III, M.D.; and Herbert O. Sieker, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1186. doi:10.7326/0003-4819-68-5-1186_2
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A high prevalence of rheumatoid factor (RF) has been reported in the serum of patients with idiopathic pulmonary fibrosis. Patients with typical rheumatoid arthritis and high titers of RF often show evidence of diffuse or localized pulmonary disease. Although pulmonary involvement occurs in patients with systemic connective tissue diseases, they rarely present exclusively with bronchopulmonary systems. We have studied eight patients with otherwise uncomplicated chronic lung disease in whom antinuclear factor (ANF) has been demonstrated. Other illnesses commonly associated with ANF were excluded. ANF was assayed by indirect double sandwich fluorescent antibody technique using monospecific goat anti-human immunoglobulin (Ig)G, IgA,


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