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Abstracts |

The Pathogenesis of Saturnine Gout: Urate Kinetic Studies.

Gene V. Ball, M.D.; and Leif B. Sorensen, M.D.
Ann Intern Med. 1968;68(5):1187. doi:10.7326/0003-4819-68-5-1187_2
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Hyperuricemia and gout have been recognized A for several centuries as complications of chronic lead ingestion. Hyperuricemia and gout have been attributed to the mild hemolytic anemia, which is part of the syndrome, and to renal retention of urate even though gout secondary to most chronic renal disease is rare.

Three negro males representative of a group of more than 20 patients with lead poisoning were studied. These patients admitted to prolonged and excessive ingestion of homemade alcohol. This illegal alcohol is commonly contaminated with lead, in amounts up to 200,000 µg/liter. Chronic lead ingestion was verified by grossly elevated


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