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Abstracts |

Glucose Intolerance and Insulin Resistance in Patients with Liver Disease.

J. R. Collins, M.D., F.A.C.P.; and O. B. Crofford, M.D.
Ann Intern Med. 1968;68(5):1187. doi:10.7326/0003-4819-68-5-1187_3
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An attempt was made to distinguish the glucose intolerance observed in patients with liver disease ("hepatogenic diabetes") from that seen in patients with genetically determined diabetes mellitus. Patients studied, matched for age and body weight, included 16 individuals with compensated liver disease, 16 with adult-onset diabetes mellitus (mean fasting serum glucose <100 mg/100 ml), and 9 controls.

Serum glucose and insulin levels were measured during oral and intravenous (60 min continuous infusion, 120 min follow-up) glucose tolerance tests (GTT). Using data from the oral GTT, insulin secretory capacity (Seltzer and associates 1967) was calculated. After intravenous infusion the rate of


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