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Studies of Calcium Kinetics in Hyperparathyroidism and in Cases of Idiopathic Renal Calculus.

Kenneth E. W. Melvin, M.R.C.P. (London); G. F. Joplin, M.R.C.P.; and T. Russell Fraser, F.R.C.P.
Ann Intern Med. 1968;68(5):1188. doi:10.7326/0003-4819-68-5-1188_3
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Studies of calcium kinetics have been carried out in 31 cases of primary hyperparathyroidism and 25 cases of normocalcemic idiopathic renal calculus, using 47Ca or stable strontium.

An increased bone uptake of tracer was found in 24 of the 31 cases of hyperparathyroidism and in 7 of the 25 cases with idiopathic calculus. The studies were abnormal in 7 out of 9 cases of hyperparathyroidism in which diagnosis proved difficult by more conventional testing.

In those cases of normocalcemic renal stone having accelerated skeletal kinetics, a significant correlation was found between the rate of bone turnover and an increased phosphaturia,


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