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Some Aspects of Calcium and Bone Metabolism in Hypothyroidism.

B. L. Riggs, M.D., F.A.C.P.; J. Jowsey, D.Phil.; P. J. Kelly, M.D.; J. D. Jones, Ph.D.; and C. D. Arnaud, M.D.
Ann Intern Med. 1968;68(5):1190. doi:10.7326/0003-4819-68-5-1190_1
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The thyroid gland produces two hormones, thyroxine (T4) and thyrocalcitonin (TC), whose absence might produce alterations in calcium metabolism. In hypothyroidism there is a low radiocalcium accretion rate, but no direct data are available in man regarding levels of bone formation and bone resorption. TC is a newly discovered calcium-lowering hormone secreted by the thyroid in response to hypercalcemia. However, its physiologic role in humans is uncertain. Studies of effects of calcium infusion in hypothyroid patients have produced conflicting results. To evaluate the effect of T4, and possibly TC, deficiency in hypothyroidism, rib biopsies from 5 hypothyroid patients were evaluated


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