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Abstracts |

Mandatory Insulin-to-Glucose Ratios to Pinpoint the Inherited Lesion of Diabetes Mellitus.

Holbrooke S. Seltzer, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1190. doi:10.7326/0003-4819-68-5-1190_2
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The following analysis of published data resolves a 20-year controversy concerning whether the inherited defect in both juvenile and adult diabetes mellitus is the same, or whether they are fundamentally different diseases. The crucial point is that, when insulin release after glucose loads is measured in normal persons and mild diabetics, comparison of insulin outputs alone yields faulty conclusions because the magnitude of insulin response has to be corrected for the intensity of glycemic stimulus that evoked it.

Six experimentally similar studies (two by the author) were analyzed identically. Oral glucose tolerance test (GTT) values and corresponding insulin values were


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