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Abstracts |

Myopathy and Metabolic Bone Disease.

Gerald Stern, M.R.C.P.; and Roger Smith, M.R.C.P.
Ann Intern Med. 1968;68(5):1190-1191. doi:10.7326/0003-4819-68-5-1190_3
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A retrospective clinical and biochemical study of 136 patients with metabolic bone disease has shown that 6 out of 91 patients with primary hyperparathyroidism and at least 20 out of 45 patients with osteomalacia developed remediable proximal muscle weakness. Myopathy may occur as a presenting complaint in the absence of symptoms or signs of bone disease and may deceptively simulate primary muscular disorders. Proximal muscular weakness was independent of plasma calcium and electrolyte concentrations. The rarity of focal weakness in uncomplicated primary hyperparathyroidism and the much more common association with osteomalacia is stressed; it is suggested that the presence of


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