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Abstracts |

Metabolic Studies on Primary Hyperoxaluria.

R. W. E. Watts, M.D., F.R.C.P.
Ann Intern Med. 1968;68(5):1191. doi:10.7326/0003-4819-68-5-1191_1
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There is a continuous high urinary oxalate excretion in primary hyperoxaluria. Glycine is a metabolic precursor of oxalate, and the relative importance of the alternative metabolic pathways from glycine to oxalate have been studied in vivo using (1-13C) glycine and (2-13C) glycine. The results indicate that the main metabolic sequence is glycine → glyoxylate oxalate but that there is also a subsidiary contribution through the sequence glycine → serine → ethanolamine → glycolic aldehyde → glycolate glyoxylate → oxalate.

The metabolism of glyoxylate has been investigated in vitro in some human tissues. Kidney tissue from two patients with primary hyperoxaluria


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