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Abstracts |

Metabolism of Lithium in the Affective Disorders.

Stanley R. Platman, M.B.
Ann Intern Med. 1968;68(5):1193. doi:10.7326/0003-4819-68-5-1193_3
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Lithium, an alkali metal, is believed to be of great value in treating the affective disorders. In our clinical research unit, we have conducted metabolic experiments that point to very little difference in the absorption and excretion of this substance in the three phases of manic-depressive illness. However, unlike other alkali metals, lithium is not uniformly distributed and, on both acute and chronic administration, has a consistent gradient in the blood-brain barrier. Various studies have established that lithium is a potent agent in the treatment and control of manic episodes, while it has little or no action upon the depressive


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