0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Case Reports |

Acute Renal Failure Complicating Rickettsial Infections in Glucose-6-Phosphate Dehydrogenase-Deficient Individuals

CAPT. ANDREW WHELTON; CAPT. JAMES V. DONADIO JR.; and BENNETT L. ELISBERG, M.D.
Ann Intern Med. 1968;69(2):323-328. doi:10.7326/0003-4819-69-2-323
Text Size: A A A
SUMMARY:

Two cases of acute renal failure in glucose-6-phosphate dehydrogenase (G-6-PD)-deficient American Negro soldiers are reported. Massive intravascular hemolysis in these patients was not due to hemolytic drugs—including antimalarial agents—but was associated with murine typhus in one case and with scrub typhus in the other. This association is described for the first time.

Peritoneal dialysis was effective in treating the acute renal failure in both cases. A phenomenon of decreased peritoneal solute clearance (urea and creatinine) during the acute hemolytic renal failure phase of the illness was noted; however, it was seen that with subsequent clinical improvement, peritoneal solute clearances returned to the usual range.

The pathogenesis of the renal failure in these patients remains speculative and may be due to the extensive intravascular hemolysis with filtration of large quantities of hemoglobin and hemoglobin cast formation superimposed on a rickettsial-induced vasculitis in the kidney.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)