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Diagnosis and Treatment |

Plague Vaccine: Recommendation on Immunization Practices

Ann Intern Med. 1968;69(2):331-332. doi:10.7326/0003-4819-69-2-331
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Plague is a sylvatic infection of rodents and their ectoparasites in many parts of the world. In the western United States, a few human cases occur each year after exposure to infected wild rodents. In some countries of Asia, Africa, and South America, epidemic plague results when the domestic rat population becomes infected. Currently the area of most intensive epidemic and epizootic infection is Vietnam.

PLAGUE VACCINE: Plague vaccines have been used since the late nineteenth century, but it has never been possible to measure their effectiveness precisely. Immunization with plague vaccine, however, is known to reduce the prevalence and


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