The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

An Improved Method of Digoxin Therapy

Ann Intern Med. 1968;69(4):703-717. doi:10.7326/0003-4819-69-4-703
Text Size: A A A

An improved method of oral digoxin therapy is discussed for euthyroid patients with normal electrolytes and gastrointestinal absorption, whose renal function may be normal, impaired, or rapidly changing.

This method aims toward a loading dose of 0.75 to 1.5 mg of digoxin in three divided doses approximately 5 hr apart.

The proper daily maintenance dose is a percentage of the loading dose given, depending upon renal function, and can be found from graphs presented.

For 95% of patients, these selected maintenance doses should sustain total body digoxin stores within 75% to 151% of the selected value (normal renal function) or within 71% to 169% of the selected value (anuria).

Caution is urged when raising total body digoxin stores above 1.7 mg in average size adults, although this is often required to control ventricular rate in patients with atrial arrhythmas.







Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.