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Optimal Duration of Treatment of Chronic Urinary Tract Infection

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Department of Medicine
University of Washington
Seattle, Wash.

Ann Intern Med. 1968;69(4):837-839. doi:10.7326/0003-4819-69-4-837
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Chronic urinary tract infections are often refractory to antimicrobial therapy or recur after cessation of treatment. The paucity of cures in these patients, even after prolonged drug therapy, may be related to factors other than the specific antimicrobial agent used. Among the possible reasons for this are failure to remedy obstruction to urine flow; renal calculi with persistence of infection; emergence of antibiotic resistant mutants during treatment; presence of "mixed infections" in which only the sensitive pathogens are eliminated with persistence of resistant strains; a milieu unfavorable to optimal action of antibiotics within the renal parenchyma; or the possibility that


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