The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

The Heart in Heart Failure

Ann Intern Med. 1968;69(5):929-940. doi:10.7326/0003-4819-69-5-929
Text Size: A A A

The inevitable occurrence of congestive heart failure in the course of chronic cardiac disease has led to much speculation concerning a possible defect in intrinsic contractile performance of the myocardium as a basis for this state. Recent evidence suggests that such a deficiency in contractile function of the myocardium is present in cardiac hypertrophy and failure. Investigative attention has been focused upon attempts to elucidate the cellular mechanismsresponsible for the alterations in myocardial performance. Present evidence indicates that the defect primarily involves the energy utilization phase of myocardial metabolism. No specific cellular locus for such a defect has been uncovered to date. It is postulated that with the development of cardiac hypertrophy ineffective coordination of the functions of the growing cellular components may account for the deficient biologic activity in the myocardium.


heart failure ; heart





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.