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Immune Serum Globulin for Prevention of Viral Hepatitis: Recommendation on Immunizing Practices: Issued by the Advisory Committee on Immunizing Practices, U. S. Public Health Service, Meeting in June 1968.

Ann Intern Med. 1968;69(5):1009-1011. doi:10.7326/0003-4819-69-5-1009
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INFECTIOUS HEPATITIS: The agent that causes human infectious hepatitis has not yet been identified but is presumed to be a virus. No vaccine is available. Administration of immune serum globulin (ISG)* to exposed persons can, however, afford a high degree of protection against infectious hepatitis. ISG substantially reduces the frequency of overt clinical disease, although inapparent infection may occur. After such infection, life-long active immunity is thought to develop.Patients with infectious hepatitis have been shown to excrete virus in stool as much as 2 to 3 weeks before and 2 weeks after onset of jaundice. Viremia has been demonstrated

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