0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Malabsorption in Pernicious Anemia

MUNSEY S. WHEBY, M.D., F.A.C.P.
Ann Intern Med. 1968;69(5):1070-1071. doi:10.7326/0003-4819-69-5-1070
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Lack of secretion of gastric intrinsic factor with resultant inadequate absorption of vitamin B12 is the hallmark of pernicious anemia. Destruction of the gastric mucosa by an autoimmune reaction is currently receiving most attention as the cause of the gastric atrophy, although the precise mechanism is still uncertain. Whatever the mechanism, progressive atrophy of the gastric mucosa occurs with virtual loss of all gastric secretions (achylia gastrica) in addition to loss of intrinsic factor. Thus, intestinal absorption might be affected deleteriously in pernicious anemia by at least two factors:

1. Digestive inadequacy owing to loss of gastric hydrochloric acid and

...

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Review: dermatitis herpetiformis. An Bras Dermatol 2013 Jul-Aug;88(4):594-9.
Polyendocrine syndrome type 3C in a family from Pakistan. Minerva Endocrinol 2013;38(3):329-36.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)