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Rheumatoid Arthritis Terminating in Heavy-Chain Disease

ZBIGNIEW A. ZAWADZKI, M.D.; THOMAS G. BENEDEK, M.D., F.A.C.P.; DANIEL EIN, M.D.; and JOHN M. EASTON, M.D.
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Pittsburgh, Pennsylvania; and Bethesda, Maryland


Ann Intern Med. 1969;70(2):335-347. doi:10.7326/0003-4819-70-2-335
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SUMMARY:

The eighth known case of heavy-chain disease is reported. Immunochemical studies of abnormal Fc fragment gamma-G3 protein and detailed morphologic, chromosomal, and electron microscopic observations are included. This patient, a 51-year-old negro man, is unique in that symptoms of heavy-chain disease began 9 years after the onset of rheumatoid arthritis. Pathologic studies failed to demonstrate malignant lymphoma.

Possible pathogenetic relationships between monoclonal paraproteinemias and rheumatoid arthritis are discussed.

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