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Proliferation of Human Abnormal Hemoglobins

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Department of Human Genetics and Simpson Memorial Institute
University of Michigan Medical School
Ann Arbor, Mich.

Ann Intern Med. 1969;70(2):417-418. doi:10.7326/0003-4819-70-2-417
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As investigators have become more peripatetic, primitive tribesmen such as the Bantus and Bushmen in Africa have undergone more careful scrutiny. Now, after examination of the blood of 304 of the latter, an inherited abnormal hemoglobin has been found (1). The hemoglobin has the mobility Hb S but does not sickle—characteristics that require its designation as a hemoglobin D. Like most of the abnormal hemoglobins detected to date, this one is responsible for only minor morphologic abnormalities of the red cells. By the technique of fingerprinting the Bushman, D hemoglobin was shown to differ from Hb A by the substitution


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