The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Portal Hypertension Without Cirrhosis in Alcoholic Liver Disease

Ann Intern Med. 1969;70(3):497-506. doi:10.7326/0003-4819-70-3-497
Text Size: A A A

In alcoholic liver disease vascular distortion by the regenerative nodule may not be a satisfactory explanation for the sinusoidal or postsinusoidal location of the vascular resistance postulated from the findings at hepatic vein catheterization. Diffuse collagen deposition in the central portion of the liver lobule after cellular injury may be a more important mechanism.

Twenty-eight patients were studied with acute alcoholic liver damage, a pathologic diagnosis of acute sclerosing hyaline necrosis, and a clinical syndrome consisting of tender hepatomegaly, jaundice, fever, abdominal pain, leukocytosis, and often ascites. Microscopic features included evidence of cellular damage, alcoholic hyalin, polymorphonuclear infiltration, and collagen deposition, predominantly centrolobularly. Regenerative nodules were not seen microscopically, and in 19 patients the liver surface was smooth when viewed at peritoneoscopy, autopsy, or surgery. All patients had portal hypertension, evidenced by elevated, wedged hepatic vein pressure (range, 6 to 20 mm Hg; mean, 13.6 mm Hg above vena caval pressure). Esophageal varices were seen in 13 patients.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Contemporary use of elastography in liver fibrosis and portal hypertension. Clin Physiol Funct Imaging Published online Oct 13, 2015;
[Functional MR imaging of the liver]. Radiologe 2015;55(12):1057-66.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.