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Pulmonary Hypertrophic Osteoarthropathy, Spider Angiomata, and Estrogen Hyperexcretion in Neoplasia

JOHN Y. JAO, M.D.; JOSEPH J. BARLOW, M.D.; and MELVIN J. KRANT, M.D.
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Boston, Massachusetts


Ann Intern Med. 1969;70(3):581-584. doi:10.7326/0003-4819-70-3-581
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SUMMARY:

Urinary estrogen and gonadotrophin were measured in four cases of hypertrophic osteoarthropathy associated with intrathoracic neoplasm. Two of these patients had florid manifestation of spider angiomatosis at a time when liver function tests were normal. Total urinary estrogen, taken as the sum of estrone, estradiol-17β, and estriol, was elevated in all cases. In the two cases where spider angiomata were present estrone and estradiol were also elevated. Gonadotrophin values were not significantly elevated in these cases. In one case removal of the primary lung tumor was followed by rapid disappearance of spider angiomata and systemic symptoms such as fever and lethargy of profound degree.

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