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Trivalent Botulinus Antitoxin

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Department of Medicine
Vanderbilt University School of Medicine
Nashville, Tenn.

Ann Intern Med. 1969;70(3):643-645. doi:10.7326/0003-4819-70-3-643
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The need for a trivalent botulinus antitoxin containing antitoxins A, B, and E has long been recognized (1, 2). Thus, the licensure of such a preparation and its availability from the National Communicable Disease Center in Atlanta is welcome news (3). Formerly, only bivalent A, B antitoxin was licensed in this country despite the increased incidence of type E disease since 1960; furthermore, from 1960 through 1967 type E botulism has had a death-to-case ratio over twice that reported for type A and four times that reported for type B disease (3). It is true that most instances of type




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