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The Course in Idiopathic Hypertrophic Muscular Subaortic Stenosis

Ann Intern Med. 1969;70(5):903-911. doi:10.7326/0003-4819-70-5-903
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Eighteen patients with idiopathic hypertrophic muscular subarotic stenosis (IHSS) have been followed for an average period of 4 years. During follow-up there has been improvement or no change in 17 patients. Two patients have improved with propranolol. No patient has had surgery, and none has died. This result is contrasted with a 19% mortality in reported surgical cases. Some of the surgical survivors have potentially serious complications, and follow-up data are sparse.

The results of this study suggest that IHSS is a disease of slow progression in most patients and that surgery should be reserved for those patients who have disabling symptoms that do not respond to medical therapy.





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