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Hemoglobin M—An Early Chapter in the Saga of Molecular Pathology

Ann Intern Med. 1969;70(5):1038-1041. doi:10.7326/0003-4819-70-5-1038
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In 1947 a meeting of the Westphalian Society for Internal Medicine in Duesseldorf was presented with a remarkable paper by a young physician and a medical student, Hoerlein and Weber, who reported their study of a family with "chronic familial methemoglobinemia and a new modification of methemoglobin" (1). The first member of this family known to have "a special kind of cyanosis" was a woman born soon after 1800 who reached the age of 84 years. Two of her sons and five of her grandchildren and great grandchildren also had cyanosis. The latter lived under the professionally sanctioned impression that


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Molecular pathology of hemoglobin M Saskatoon disease. Biomed Biochim Acta 1990;49(2-3):S317-22.
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