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Steroid Inhibition of Adrenal Corticosteroid Production—A Mitochondrial Effect.

Gerard N. Burrow, M.D., F.A.C.P.
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New Haven, Connecticut


Ann Intern Med. 1969;70(5):1060-1061. doi:10.7326/0003-4819-70-5-1060_2
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There is evidence to suggest that certain steroids are capable of inhibiting corticoid production as well as protein and ribonucleic acid (RNA) synthesis in rat adrenal glands in vitro. The data suggest the possibility of local feedback inhibition of steroidogenesis by adrenal steroids, but the mechanism of the inhibition is not clear. The finding that the addition of adenine triphosphate (ATP) and an ATP-generating system overcame corticosterone inhibition of 14C-leucine incorporation into rat adrenal protein in vitro suggested an inhibitory effect on cellular energy processes. To study this further, rat adrenal mitochondria were prepared by differential centrifugation, and the effect

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