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Abstracts |

Inhibition of Insulin Secretion by Catecholamines in Pheochromocytoma.

John A. Colwell, M.D.
Ann Intern Med. 1969;70(5):1061. doi:10.7326/0003-4819-70-5-1061_1
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Catecholamine-induced inhibition of pancreatic insulin release is reversed by alpha adrenergic blockade with phentolamine. These observations suggest that the abnormal glucose tolerance and depressed plasma insulin concentrations of subjects with pheochromocytoma may be due to alpha receptor stimulation by catecholamines. Plasma glucose and insulin responses to oral or intravenous glucose were investigated pre- and postoperatively in four patients with pheochromocytoma. In two subjects intravenous glucose tolerance and insulin response were measured before and after alpha adrenergic blockade with phentolamine, preoperatively.

Abnormal glucose tolerance tests and blunted plasma insulin response returned to normal in three patients and improved in the fourth


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