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Prevention of Hypercalcemia (Ca ↑) in Vitamin (D) Therapy of Hypoparathyroidism (HoPT).

A. M. Parfitt, M.R.C.P.
Ann Intern Med. 1969;70(5):1064-1065. doi:10.7326/0003-4819-70-5-1064_2
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In view of dissatisfaction frequently expressed with current therapy of hypoparathyroidism, the incidence of hypercalcemia and its precipitating factors were studied in 21 patients with hypoparathyroidism followed for 1 to 6 years (mean, 3.5 years). Six patients—three postsurgical, two idiopathic, and one pseudo—were calcium-loaded (2.0 g/day) and calcium-deprived with cellulose phosphate, 15.0 g/day, and a low calcium diet; and 2 were phosphorus-loaded (2.0 g/day) and phosphorus-deprived. In all patients thyroid status was classified into grades I, II, and III according to the criteria of Canary and associates (Clin. Res. 16: 74, 1968). For this purpose, thyroid tissue was considered absent


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