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Prolonged Observations on the Liver Function Tests in Infectious Hepatitis.

G. Thomas Strickland, M.D.; Donald O. Castell, M.D.; and Richard A. Kronmal, Ph.D.
Ann Intern Med. 1969;70(5):1071-1072. doi:10.7326/0003-4819-70-5-1071_2
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Military personnel hospitalized with infectious hepatitis at most U. S. Naval Hospitals are discharged only after complete resolution of all clinical and laboratory abnormalities. A unique opportunity to follow closely the course of infectious hepatitis is thus provided. Standard liver function tests were followed from 7 to 256 (mean, 66) days after onset of illness in 215 patients admitted to Great Lakes and Bethesda Naval Hospitals.

In all patients, mean-total and direct bilirubin concentrations reached normal levels by the seventh and eleventh weeks, respectively. Alkaline phosphates returned to normal by the ninth week. Sulfobromophthalein (BSP) retention at 45 min was


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