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Abstracts |

Circulating Immunoglobulins, Intestinal Protein Loss, and Malabsorption in Intestinal Capillariasis.

G. E. Whalen, M.D.; E. B. Rosenberg, M.D.; and G. T. Strickland
Ann Intern Med. 1969;70(5):1072. doi:10.7326/0003-4819-70-5-1072_1
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Capillaria philippinensis, a newly described species of roundworm, caused an epidemic of diarrhea in the Philippines involving 1,300 people over 19 months. The characteristic clinical picture of abdominal pain, diarrhea, and edema in patients with intestinal capillariasis was associated with a protein-losing enteropathy (PLE), malabsorption, and a high mortality. Deficient immunoglobulin synthesis has recently been proposed as a mechanism for PLE and malabsorption. The purpose of this study was to determine whether a defect in immunoglobulin synthesis was responsible for the PLE and malabsorption in capillariasis. Quantitative immunoglobin determinations were performed on plasma from 11 control subjects and 22 patients


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