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Amino Acid Excretion in Alcoholic Cirrhosis.

Horace H. Zinneman, M.D., F.A.C.P.; Richard P. Doe, M.D., F.A.C.P.; and Ulysses S. Seal, Ph.D.
Ann Intern Med. 1969;70(5):1072. doi:10.7326/0003-4819-70-5-1072_2
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It appears to be generally accepted that Laënnec's cirrhosis is associated with aminoaciduria. Recent reports by Dent and Knauff tended to place this concept on an insecure basis. Our measurements of free amino acids in plasma and urine were performed by ion-exchange chromatography on columns of Amberlite resin (Spinco aminoacid analyzer). The 24-hr urine excretion of free amino acids was related to the patient's weight. Seven patients were studied during precoma and upon maximal improvement. Contrary to most earlier reports the changes were found to be unspectacular. Plasma concentrations of amino acids proved to be remarkably stable. The urinary excretions


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