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Propranolol in the Long-Term Treatment of Angina Pectoris.

Howard J. Zeft, M.D.; Sandra D. Patterson, B.S.; and Edward S. Orgain, M.D., F.A.C.P.
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Durham, North Carolina


Ann Intern Med. 1969;70(5):1082. doi:10.7326/0003-4819-70-5-1082_1
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There is increasing evidence that propranolol hydrochloride, a beta-adrenergic receptor blocking agent, may be a useful adjunct in the treatment of angina pectoris. The effect of this agent in the long-term management of 65 patients with severe ischemic (coronary) heart disease was evaluated. Fifty-seven patients received propranolol for 6 to 24 months. Sixty-five percent of the patients exhibited a sustained 50% or more reduction both in frequency of anginal pain and in nitroglycerin requirement. For a given patient there was a dose threshold, between 160 and 400 mg/day, at which maximum relief of symptoms was attained. The reduction of resting

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