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Abnormal Immune Response to Keyhole Limpet Hemocyanin (KLH) in Patients with Multiple Myeloma.

Jules Harris, M.D., F.A.C.P.; Raymond Alexanian, M.D.; Evan M. Hersh, M.D.; and Philip Migliore, M.D.
Ann Intern Med. 1969;70(5):1084. doi:10.7326/0003-4819-70-5-1084_1
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Twenty-three patients (11 men with age range of 56 to 81 years—median, 62; 12 women with age range of 39 to 78 years—median, 62) with multiple myeloma were immunized with 5 mg keyhole limpet hemocyanin given subcutaneously. The distribution of myeloma protein types was as follows: gamma GK, 8 patients; gamma G L, 6; gamma A K, 2; gamma A L, 3; Bence Jones protein only: K, 3 and L, 1. Humoral antibody formation of 7S and 19S type, in vivo delayed hypersensitivity, and in vitro lymphocyte transformation were studied serially. Nine of 11 patients studied developed normal diameter skin


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