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Bacterial Endocarditis from 1938 to 1967 at the Presbyterian Hospital in New York City.

Charles Cherubin, M.D.; and Harold C. Neu, M.D., F.A.C.P.
Ann Intern Med. 1969;70(5):1089. doi:10.7326/0003-4819-70-5-1089_2
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The records of 900 patients indexed as having bacterial endocraditis between 1938 and 1967 were reviewed. Seven hundred records contained sufficient clinical and bacteriological data to confirm the diagnosis. Definite changes in the nature of the disease were noted throughout the three decades. The introduction of penicillin caused a marked fall in the case fatality rate. Except for the disappearance of endocarditis caused by Diplococcus pneumoniae and Neisseria gonorrhoeae antibiotics did not change the type of organisms or heart value affected. In the last 2 decades the following changes occurred: Older patients and patients lacking a history of rheumatic heart


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