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Immunological Studies of Anemia in Malaria.

Eugene B. Rosenberg, M.D.; G. Thomas Strickland, M.D.; George E. Whalen, M.D.; John E. Kostinas, M.D.; and Liang S. Yang, M.D.
Ann Intern Med. 1969;70(5):1092. doi:10.7326/0003-4819-70-5-1092_1
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The anemia of malaria cannot be attributed solely to erythrocytic destruction by malarial parasites since the anemia is often out of proportion to the parasitemia. The possibility of an immunologic mechanism contributing to the pathogenesis of this anemia was studied in 38 individuals with falciparum malaria and in 13 controls. Acute and convalescent plasma samples from American soldiers in Vietnam were assayed for IgA, IgG, IgM, and complement by a radial immunodiffusion technique.

The mean IgM level in acute patients was 1.6 times the control mean (P < 0.05), and in convalescent patients the mean IgM level was 2.3 times



anemia ; malaria

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