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Abstracts |

Renal Disease in Acute Rheumatic Fever.

Seymour Cohen, M.D.; Mardoqueo L. Salomon, M.D.; Edith Grishman, M.D.; Donald Gribetz, M.D.; and Jacob Churg, M.D.
Ann Intern Med. 1969;70(5):1093-1094. doi:10.7326/0003-4819-70-5-1093_3
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Although antecedent streptococcal infection is involved in the pathogenesis of both rheumatic fever and glomerulonephritis, their simultaneous appearance and even their occurrence at different times in the same individual have been considered rare. Therefore, a study was undertaken by renal biopsy to determine the extent to which renal disease occurs in patients with acute rheumatic fever. Twenty-six patients were studied. Almost all had an elevation of antistreptolysin 0 antibody titer above 500 Todd units. Five of 10 adults and 9 of 16 children had clinical or laboratory evidence, or both, of renal disease. Of these, all had some proteinuria, two


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